KMID : 0379119800080010069
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Korean Journal of Mycology 1980 Volume.8 No. 1 p.69 ~ p.71
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A Study on the Microbiological Assay of Bacampicillin Hydrochloride
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Abstract
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To establish a competent method of microbiological assay for bacampicillin, one of new semi-synthetic derivatives of ¥â-lactam antibiotics, a comparison was carried out between different conditions for hydrolysis of bacampicillin into ampicillin which was then subjected to cylinder plate method. The results showed that the use of carboxylic ester hydrolase in vitro as a pretreatment of it in either pH value 6 or 8 was feasible and that the cylinder plate method with Sarcina lutes was adequate for potency estimation.
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